Replicine Functional Keratin wound dressings absorb and interact with wound fluid to form a soft, hydrophilic keratin gel that facilitates a moist healing environment. A cell friendly structural framework is also provided to the wound, encouraging cell migration and differentiation.
Proven Results
Improvements of 26% in the rate of epithelialization of acute wounds have been identified in studies on Replicine Functional Keratin dressings conducted by the University of Miami.6Further work has identified the ability of Replicine Functional Keratin to promote keratinocyte cells to quickly enter a natural healing phase and express important structural proteins required for wound healing.7
Encouraging epithelialization through improved keratinocyte growth is an important part of achieving a good healing outcome.
Hard to heal chronic wounds have been established as having an expected healing rate of 13% in international studies. Studies on Replicine Functional Keratin dressings show a 71% healing rate for this wound type.4,8 In addition a strong preference was noted by both patients and nurses for keratin based dressings over previous wound technologies used on a wide range of chronic wounds.9
Substantial improvement in skin structure and robustness is reported in the use of Replicine Functional Keratin to treat the severe blistering disorder epidermolysis bullosa, a condition with currently no effective treatment.1,2
Research into the skin structure improvement resulting from Replicine Functional Keratin application is ongoing.
Review a case study summary of the use of Keragel T for the management of wounds in epidermolysis bullosa…
EB publications
1 S Cassidy, M Than, Improved healing of Epidermolysis Bullosa wounds using a novel keratin gel technology, Australian Wound Management Association conference proceedings, May 2008.
2 R.Kirsner Use of topical keratin gel by patients with epidermolysis bullosa, Journal of the American Academy of Dermatology, March 2009 (Vol. 60, Issue 3, Supplement 1, Page AB202)
Chronic wound and acute wound healing
3 R Kelly, F Sigurjonsson, R A Smith, A Ali, M Than, R Mcpherson, C Hammond, Keratin biopolymer dressings for wound care, Symposium on Advanced Wound Care conference proceedings, 2006.
4 R Kelly, F Sigurjonsson, R A Smith, A Ali, M Than, R Mcpherson, C Hammond, Acceptability and Efficacy of Keratin-Based Dressings in the Chronic Wound, European Wound Management Association 2007 conference proceedings.
5 W Thompson, S Hanneke, M Compton, L Burrage, K Butler, A keratin matrix interface in negative pressure wound therapy, Clinical Symposium on Advances in Skin and Wound Care, Las Vegas Oct 26-30, 2008.
6 S Davis, R Perez, Y Rivas, J Gil, J Valdes, and R Kirsner, The effect of a keratin based dressing on the epithelialization of deep partial thickness wounds, Journal of the American Academy of Dermatology March 2009 (Vol. 60, Issue 3, Supplement 1, Page AB201)
7 R Perez, R Kirsner, J Gil, J Valdes, S Davis, Evaluation of the effects of two keratin formulations on wound healing and keratin gene expression in a porcine model, Symposium on Advanced Wound Care conference presentation, April 2009.
8 M Than, C Hammond, R A. Smith, C Marsh, R Kelly, P Rohricht, R S Kirsner, A Prospective Pilot Study of Keratin Dressings: Effectiveness on Refractory (Large and of Long Duration) Venous Leg Ulcers SAWC, April 2010, Orlando, Florida.
9 C Hammond, M Than, J Walker. From the laboratory to the leg: Patient's and nurses perceptions of product application using three different dressing formats, Wound Practice and Research, 18, 4, 189-195, November 2010.
