Replicine™ has evolved from decades of scientific research. Built on a knowledge base of 40 years at the forefront of keratin and wool science, 20 years of fundamental and applied keratin science has created a remarkable technology platform and manufacturing base to delivery Replicine™ Functional Keratin® technology solutions across a range of personal care, health care, nutritional and industrial applications.

Replicine™ is different from other keratin related technologies in three important ways, each of which affects the physical and biological performance of products incorporating Replicine™ Functional Keratin® technology.

Respect nature’s complexity

Nature has evolved a family of keratin proteins with different family members chosen for different roles. In skin, keratin intermediate filament proteins are the core structure of all cells, as well as being the most abundant material in the outer layers of the skin, performing a physical role in maintaining cell structure as well as biological role in helping cells make a wide range of essential proteins for healthy skin structure. In hair, the fibrous keratin intermediate filaments are responsible for tensile strength, whereas the globular keratin matrix proteins act as the glue that keeps the hair structure together. Replicine™ Functional Keratin® technology understands and respects the roles that keratins play in the body and isolates each of these types of keratins separately. For example, some Replicine™ Functional Keratin® products incorporate keratin intermediate filament proteins. When applied to skin these proteins encourage skin cells to make more of the essential proteins needed for healthy skin structure and repair, in particular the collagen 4 and collagen 7  responsible for the strong dermal-epidermal junction that becomes weakened during the ageing process. In hair, these proteins repair hair strength by rebuilding damaged keratin intermediate filaments within the fiber. Other keratin technologies cannot distinguish between these different keratin types and treat all family members as one

Maintain form and therefore function

Keratin protein structure is essential to physical and biological function. The Replicine™ Functional Keratin technology® can keep large fibrous proteins intact, using them without breaking important bonds within the protein. These large molecular weight proteins can then be used to build tough structures, such as protective films on a hair fiber surface, wound care membranes or biodegradable plastics. Other keratin technologies often use only hydrolysis, breaking important bonds within the protein and losing the ability of the protein to build tough structures.

The amino acids in keratins are linked in a particular sequence. Within keratin materials, such as skin and hair, these sequences coil together like small bundles of rope, to build strong protein networks. The particular amino acids in the coil link, like teeth in a zipper, to lock the structure in place. This structure is essential for the protein to perform its role, either in helping skin cells make proteins or in keeping hair strong and flexible.

We have identified the specific amino acid sequences needed for this zipper effect, and ensured that they are maintained in our Replicine™ Functional Keratin® proteins. The same sequences are present in human skin and hair and so Replicine™ Functional Keratin® proteins can be considered skin and hair identical proteins. Other keratin technologies break up the proteins and damage the amino acids, and so loose the important "teeth in the zipper" needed for good binding, essential for biological performance and genuine hair repair.

molecule and zipper comparison 

Control the sulfur amino acids

Keratin proteins are characterized by the highest content of the sulfur amino acid cystine of any protein source, 3-10 times higher than the next most abundant protein source.

Cystine and sulfur metabolism is essential in the body for physical and biological performance. Cystine is the body the essential building block of glutathione, the body's weapon of choice to protect each and every cell in the body, including skin and hair, from oxidative stress. Cystine is also essential for crosslinking keratin structures such as healthy strong nails and hair.

Replicine™ Functional Keratin® technology protects and controls the amino acid cystine to ensure it is available to the body to support the cell's biological pathways or to link to physical structures together. Other keratin technologies destroy the amino acid cystine in an effort to make keratin soluble and so lose the important cystine functionality.

Core to the development of the Replicine™ Functional Keratin® technology are the principles of scientific and medical research, an evidence base for our product performance and peer review scientific publication of our results. This is the gold standard in validating new knowledge. Our medical products are founded on this platform and we apply the same standard of proven efficacy to all of our products so our customers know that Replicine™ Functional Keratin® will deliver the results our claims promise.